Charles was a visionary, a fearless leader, and a force to be reckoned with. He liked straightforward talking and getting things done. He founded the Department of Biomedical Engineering at the University of Michigan in 1996, which now has top 10 undergraduate and graduate BME programs in the US. Beyond all his academic achievements, Charles was born in Tampa Florida, and raised in Miami Florida. He had a deep love of hiking and camping in the mountains, and his ashes will be distributed in Wind River Mountains in Wyoming, which was his favorite camping destination. Above all, Charles was a beloved husband, father, and grandfather. He is survived by his wife, Li, three sons, Kent, James, and Robert, and grandchildren Travis, Jenna. He will be dearly missed by many people as a creative researcher, a caring mentor, a fearless leader, and a beloved family member. A fellowship for PhD students at the Department of Biomedical Engineering at the University of Michigan in memory of Prof. Cain has been set up. If you would like to contribute, you can donate to the fellowship fund via the link below: https://donate.umich.edu/POlbg. Professor Charles Cain passed away on March 27, 2020, at the age of 77, after a three year fight with prostate cancer.